ERBB2-Mutated Stage III Lung Cancer With Liver Recurrence and Multiple Lines of Therapy

Patient Info: Anonymized, female, 60s | Stage IV

Biomarkers: ERBB2 exon 20 insertion

Metastatic Site: liver

After 6 months of disease control on vinorelbine plus trastuzumab, the cancer progressed in all sites and she chose hospice care.

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Stage IV ERBB2-Mutated Lung Cancer With Extensive Bone Metastases

Patient Info: Anonymized, female, 60s | Stage IV

Biomarkers: ERBB2 exon 20 insertion. A PIK3CA mutation was later detected at progression and considered a possible resistance mechanism.

Metastatic Site: bone

After progression on pemetrexed following several earlier treatment lines, she transitioned to hospice care.

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Stage IV ERBB2-Mutated Lung Adenocarcinoma With Brain Metastases and Multiple Targeted Therapies

Patient Info: Anonymized, female, Under 40 | Stage IV

Biomarkers: ERBB2 exon 20 insertion, exact sequence not specified. ERBB2 copy-number gain was identified during progression on afatinib.

Metastatic Site: brain, adrenal gland, liver

The final documented afatinib plus bevacizumab rechallenge produced a mixed response followed by liver progression after 3 months.

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ERBB2-Mutated Metastatic Lung Adenocarcinoma Progressing Through Multiple Therapies

Patient Info: Anonymized, female

Biomarkers: ERBB2 mutation

The cancer progressed during afatinib, nivolumab and a later paclitaxel rechallenge.

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Lung Cancer: Diego's Patient Story

Patient Info: Diego, Male | Stage Metastatic/Advanced

Metastatic Site: Hip / left iliac region pain treated with radiotherapy

On 27 March 2017, Diego was recovering from hospitalization and radiotherapy for severe hip/left iliac-region pain, with pain improved and pemetrexed chemotherapy planned after his next oncology visit.

Stage III Ovarian Cancer: Pam's Survivor Story

Patient Info: Pam Scarpino, female | Stage III

Pam had no evidence of disease in March 2010 after treatment for recurrence and remained in remission at the time of the story.

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Stage III Rectal Cancer Among Five Synchronous Gastrointestinal Cancers

Patient Info: Anonymized, male, 50s | Stage III

Six years after surgery and adjuvant treatment, he remained without recurrence or metastasis and continued regular follow-up.

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Stage IV HER2-Positive Breast Cancer: Sarah's Patient Story

Patient Info: Sarah, Female, Under 40 | Stage IV

Biomarkers: HER2-positive; BRCA and other known hereditary breast cancer genes not identified in family history discussion

As of January 2017, Sarah had been living for almost 3 years with recurrent Stage IV HER2-positive breast cancer and was receiving Kadcyla every 3 weeks.

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Colorectal Cancer: Theresa's Survivor Story

Patient Info: Theresa Cotton, Female, 40s

As of January 2017, Theresa was cancer-free for more than 5 years after colorectal cancer treatment that included complete hysterectomy, permanent colostomy, chemotherapy and 28 radiation treatments.

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Stage IV Breast Cancer: Debora's Patient Story

Patient Info: Debora, Female, 60s | Stage IV

Debora was living with metastatic breast cancer after Stage III disease treated with surgery, chemotherapy, radiation therapy, and targeted therapy; four years after surgery, she was told the cancer had metastasized and was on targeted therapy.

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Stage II Breast Cancer: Tasha's Patient Story

Patient Info: Tasha | Stage II

She completed surgery and radiation and is doing well as a survivor while continuing tamoxifen.

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Stage II Breast Cancer: Natalia's Survivor Story

Patient Info: Natalia | Stage II

Natalia was declared cancer-free on February 21, 2024, and continued regular follow-up while taking letrozole.

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Stage III Colorectal Adenocarcinoma: Anne's Survivor Story

Patient Info: Anne, Under 40 | Stage III

Anne was declared cancer-free in December 2017 and reports doing well 7 years after treatment.

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Stage III Breast Cancer: Elizabeth's Survivor Story

Patient Info: Elizabeth, 40s | Stage III

Biomarkers: Cancer described as highly hormone-dependent.

Elizabeth said she was in remission and no longer required treatment after lumpectomy, chemotherapy, radiation, and an aromatase-inhibitor clinical trial.

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Lung Adenocarcinoma Metastatic to the Breast With Inflammatory Breast-Like Symptoms

Patient Info: Anonymized, female, 60s | Stage IV

Biomarkers: EGFR positive. Breast metastasis: TTF-1 positive

Metastatic Site: right breast

A PET scan after breast radiation showed no metabolically active cancer, but she died 2 months after the breast metastasis was diagnosed.

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Stage III Inflammatory Breast Cancer Diagnosed After Severe Breast Pain and Swelling Following Mammography

Patient Info: Anonymized, female, 60s | Stage IV

Biomarkers: ER negative, PR negative, HER2 highly positive

After later metastatic disease was found, she chose no further active treatment and died of progressive disease in 2012.

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Breast Cancer: Stephanie's Survivor Story

Patient Info: Stephanie Spiesz, Female, 50s

As of June 2016, Stephanie was fully recovered and cancer-free after breast cancer diagnosed in November 2013 and treated with double mastectomy, chemotherapy and radiation.

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Colorectal Cancer: Steve's Survivor Story

Patient Info: Steve B, Male, Under 40

As of April 2016, Steve had completed chemoradiation, colon resection with temporary ileostomy, additional chemotherapy and ileostomy reversal, and his oncologist described him as doing beautifully; no explicit NED/cancer-free status was stated.

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Colorectal Cancer: Ed's Patient Story

Patient Info: Ed Godic, Male, 60s

As of April 2016, Ed had completed 28 radiation treatments and rectal resection with temporary ileostomy, spent 4 days in the hospital, and remained on regular testing and medical care while recovering.

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Stage I Breast Cancer: Shirley's Survivor Story

Patient Info: Shirley | Stage I

Shirley says she completed treatment and is now in remission after Stage I breast cancer.

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Stage II Invasive Ductal Carcinoma: Sarah's Patient Story

Patient Info: Sarah Cawley, Female, Under 40 | Stage II

As of August 2015, Sarah was still receiving treatment for Stage II invasive ductal carcinoma after modified radical mastectomy, 6 chemotherapy cycles, 25 radiation treatments and clinical trial participation.

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Stage IV Colorectal Cancer: Dawn's Survivor Story

Patient Info: Dawn Eicher, Female, Under 40 | Stage IV

Metastatic Site: liver

After treatment for Stage IV colorectal cancer and a later recurrence, Dawn had 2 consecutive scans showing no evidence of disease and had been cancer-free for 8 months.

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Stage II Colorectal Cancer: Li's Survivor Story

Patient Info: Li Bing | Stage II

Li Bing was declared cancer-free in September 2022, nearly 7 years after the October 2015 Stage II rectal carcinoid diagnosis.

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Malignant Struma Ovarii With Papillary Thyroid-Type Cancer

Patient Info: Anonymized, female, 40s

Biomarkers: KRAS mutation

Radioactive iodine scans showed no local or distant disease, and she was well and symptom-free 12 months after the initial diagnosis while continuing follow-up.

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