Metastatic Breast Cancer and an Atypical Femoral Fracture During Ibandronate Treatment

Patient Info: Anonymized, female, 50s

She was living with bone-metastatic breast cancer when a suspected new femoral metastasis was instead recognized as an atypical femoral fracture during long-term ibandronate treatment.

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Stage IV HER2-Positive Breast Cancer: Sarah's Patient Story

Patient Info: Sarah, Female, Under 40 | Stage IV

Biomarkers: HER2-positive; BRCA and other known hereditary breast cancer genes not identified in family history discussion

As of January 2017, Sarah had been living for almost 3 years with recurrent Stage IV HER2-positive breast cancer and was receiving Kadcyla every 3 weeks.

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Stage IV Breast Cancer: Debora's Patient Story

Patient Info: Debora, Female, 60s | Stage IV

Debora was living with metastatic breast cancer after Stage III disease treated with surgery, chemotherapy, radiation therapy, and targeted therapy; four years after surgery, she was told the cancer had metastasized and was on targeted therapy.

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Breast Cancer: Amanda's Survivor Story

Patient Info: Amanda

Biomarkers: CDH1 gene deletion

About 7 years after gastrectomy and mastectomy, Amanda said all of the cancer had been removed, although long-term effects of surgery continued to affect daily life.

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Stage II Breast Cancer: Natalia's Survivor Story

Patient Info: Natalia | Stage II

Natalia was declared cancer-free on February 21, 2024, and continued regular follow-up while taking letrozole.

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BRCA1 Non-Small Cell Lung Cancer: Nadine's Survivor Story

Patient Info: Nadine Beech, Female, Under 40

Biomarkers: Germline BRCA1 mutation for hereditary breast/ovarian cancer risk; lung cancer biomarker not reported

As of November 2016, Nadine was cancer-free after right bilobectomy for recurrent non-small cell lung cancer, following 19 years of lung cancer management that included left lower lobectomy, surveillance, Tarceva, and risk-reducing surgery for germline BRCA1.

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Male Breast Cancer Treatment Complicated by Stevens-Johnson Syndrome

Patient Info: Anonymized, male, 60s

After the third chemotherapy cycle he developed severe Stevens-Johnson syndrome with disseminated intravascular coagulation and multiorgan failure, and he died after care was shifted to comfort measures.

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Stage III HER2-Positive Invasive Ductal Carcinoma: Dorothy's Survivor Story

Patient Info: Dorothy Paterson, Female, 40s | Stage III

Biomarkers: HER2-positive

As of November 2016, Dorothy had remained cancer-free since completing treatment for Stage III HER2-positive invasive ductal carcinoma in April 1999.

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Stage III Inflammatory Breast Cancer Diagnosed After Severe Breast Pain and Swelling Following Mammography

Patient Info: Anonymized, female, 60s | Stage IV

Biomarkers: ER negative, PR negative, HER2 highly positive

After later metastatic disease was found, she chose no further active treatment and died of progressive disease in 2012.

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HER2-Positive Right Breast Cancer With Complete Response Before Bilateral Mastectomy

Patient Info: Anonymized, female, 50s

Biomarkers: ER negative, PR negative, HER2 positive

After neoadjuvant treatment, imaging showed complete resolution of the right-breast mass and mastectomy pathology found no residual right-breast tumor or malignant right sentinel node.

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Unexpected Hormone-Receptor-Positive Left Breast Cancer Found at Bilateral Mastectomy

Patient Info: Anonymized, female, 50s

Biomarkers: ER positive, PR positive, HER2 negative

The incidental left-breast cancer was removed during mastectomy, and hormonal therapy with left-axillary imaging follow-up was planned.

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Breast Cancer: Stephanie's Survivor Story

Patient Info: Stephanie Spiesz, Female, 50s

As of June 2016, Stephanie was fully recovered and cancer-free after breast cancer diagnosed in November 2013 and treated with double mastectomy, chemotherapy and radiation.

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Stage II Invasive Ductal Carcinoma: Sarah's Patient Story

Patient Info: Sarah Cawley, Female, Under 40 | Stage II

As of August 2015, Sarah was still receiving treatment for Stage II invasive ductal carcinoma after modified radical mastectomy, 6 chemotherapy cycles, 25 radiation treatments and clinical trial participation.

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Stage II BRCA1 Breast Cancer: Mariana's Patient Story

Patient Info: Mariana Torrado, female, Under 40 | Stage II

Biomarkers: BRCA1 positive

After breast cancer treatment and reconstruction, the patient described herself as a breast cancer survivor and was returning to normal activities.

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Invasive Lobular Carcinoma: Gretchen's Survivor Story

Patient Info: Gretchen Borzi, Female

Biomarkers: germline CDH1 mutation

The invasive focus measured less than 0.75 mm and had been removed during biopsy; surgery found no nodal spread.

Pediatric triple-negative breast carcinoma: modified radical mastectomy and tumor-free follow-up

Patient Info: Anonymized, Female, Under 40

Biomarkers: ER-negative; PR-negative; HER2-negative

As of April 2014, she was tumor-free after modified radical mastectomy and axillary clearance for pediatric triple-negative breast carcinoma.

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Mixed epithelial and mesenchymal metaplastic breast carcinoma: no recurrence 1 year after surgery and adjuvant therapy

Patient Info: Anonymized, Female, 40s

Biomarkers: Mixed metaplastic breast cancer: epithelial part ER/PR/HER2-positive; mesenchymal part ER/PR-negative with weak HER2. Ki-67 ~20%.

As of March 2014, she was doing well with no recurrence or metastasis 1 year after modified radical mastectomy, adjuvant CEF/Taxotere chemotherapy, and tamoxifen.

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Breast invasive ductal carcinoma with coexisting inflammatory myofibroblastic tumor: disease-free after mastectomy, TAC, and tamoxifen

Patient Info: Anonymized, Female, Under 40

Biomarkers: Breast cancer: ER/PR-positive with HER2 2+ and p53-positive. Separate inflammatory myofibroblastic tumor had ALK/vimentin/actin/S-100 markers.

As of August 2013, she remained disease-free 2 years after modified radical mastectomy, 6 courses of TAC chemotherapy, and tamoxifen.

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ER/PR-positive mucinous breast cancer treated with mastectomy and tamoxifen

Patient Info: Anonymized, Female, Under 40

Biomarkers: ER-positive; PR-positive; HER2/neu not overexpressed; no pathogenic BRCA1 or BRCA2 mutations identified; chromosome 13q34 duplication

After radical right mastectomy with nipple and areola preservation followed by tamoxifen, she showed no evidence of local recurrence or metastasis of breast cancer.

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Stage IV ER/PR-positive mucinous breast cancer: long-term no evidence of disease after surgery, AFTV, radiation, CEF, and endocrine therapy

Patient Info: Anonymized, Female, 50s | Stage IV

Biomarkers: ER-positive; PR-positive; delayed-type hypersensitivity to AFTV became pseudo-positive after vaccination and remained pseudo-positive 5.4 years later

Metastatic Site: Th7 vertebra

More than 6 years after primary surgery, she remained well with no evidence of vertebral metastasis activity, new metastasis, or local recurrence.

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ER-positive breast cancer recurrence with renal metastasis inside angiomyolipoma

Patient Info: Anonymized, Female, 60s | Stage IV

Biomarkers: ER-positive; mammaglobulin-positive; e-cadherin-positive; GCDFP-15-positive; melan A positive in angiomyolipoma component

Metastatic Site: right subpectoral lymph node, left kidney

At 7 months after nephrectomy, she continued anti-estrogen hormonal therapy with no demonstrable progression of disease; surgical excision of the subpectoral lymph node was offered but declined.

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BRCA1-associated right invasive ductal carcinoma followed by left acinic cell carcinoma of the breast

Patient Info: Anonymized, Female, 40s

Biomarkers: Constitutional BRCA1 mutation. Right breast cancer was ER/PR positive, HER2 negative; later left tumor was triple-negative with TP53 change.

After treatment for right invasive ductal carcinoma and later contralateral acinic cell carcinoma, she was alive and well 19 months after the acinic cell carcinoma surgery, with no evidence of disease while continuing hormonal therapy.

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Hormone-positive breast cancer with axillary recurrence responding to hyperthermia, radiation, and chemotherapy

Patient Info: Anonymized, Female, 60s

Biomarkers: ER-positive; PR-positive; HER2-negative

The left axillary recurrence enlarged during weekly paclitaxel and radiotherapy, then became nearly flat and was assessed as a complete response 8 weeks after adding hyperthermia.

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Male DCIS breast cancer treated with mastectomy and negative sentinel node

Patient Info: Anonymized, Male, 60s | Stage 0

Biomarkers: ER-positive; PR-positive

Completed surgical treatment for Stage 0 DCIS with negative sentinel lymph node biopsy and clear margins; no additional cancer-directed therapy was described.

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