Stage IV Colorectal Cancer: Uwe's Patient Story

Patient Info: Uwe Dierks, Male, 60s | Stage IV

Biomarkers: Not reported; family history of colorectal cancer in mother

Metastatic Site: Lung

As of July 2023, Uwe was living after rectal cancer, lung metastasis treatment, permanent stoma placement, multiple complications, and ongoing pancreatic-insufficiency and quality-of-life challenges.

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Sydney Stoner: Stage IIIB to Stage IV colon cancer with liver and lung involvement

Patient Info: Sydney Stoner, Female, Under 40 | Stage IV

Metastatic Site: Liver; lungs

Progressed from Stage IIIB colon cancer to Stage IV disease involving the liver and lungs; treated with surgery/ileostomy/reversal, FOLFOX/FOLFIRI, lung radiation, liver ablation/resection, capecitabine, and ongoing Lonsurf + Avastin.

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Stage IV Colorectal Cancer: Janice's Patient Story

Patient Info: Janice Johnson, Female, 40s | Stage IV

Biomarkers: CEA tumor marker elevated after colectomy; biomarker/genomic test results not reported

Metastatic Site: Lungs

Ongoing care for Stage IV colorectal cancer after colectomy, years of chemotherapy, radiation, lung resections for metastatic disease, and pelvic stent exchanges every 3 months.

Stage IV Non-Small Cell Lung Cancer: Amy's Patient Story

Patient Info: Amy, Female | Stage IV

Metastatic Site: Neck lymph node; bones — hips, femurs, foot; adrenal…

Living 5 years after Stage IV squamous NSCLC diagnosis, after Keytruda did not work and treatment included bone radiation, SBRT to the lung nodule, and adrenal cryoablation.

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Stage IV Colorectal Cancer: Hong's Patient Story

Patient Info: Hong Wentong, Male | Stage IV

Metastatic Site: Liver

Responded well to interventional therapy plus radioactive seed implantation for Stage IV sigmoid colon cancer with liver metastasis, with liver tumor shrinkage, better disease control, and 3 kg weight gain.

Colorectal Cancer: Hatta's Survivor Story

Patient Info: Hatta, Male

No recurrence reported after interventional therapy, biological immunotherapy, Chinese medicine, and local radiotherapy for rectal cancer; later CT report was described as showing no cancer cells, with 8 years of normal life and annual checks.

Stage IV Colorectal Cancer: Antonio's Patient Story

Patient Info: Antonio, Male, 40s | Stage IV

Metastatic Site: Liver

Improved significantly after cryotherapy, interventional therapy, and bio-immunotherapy for Stage IV sigmoid colon cancer with liver metastasis; no NED/remission statement is reported.

Stage IV Colorectal Adenocarcinoma: Adrienne's Patient Story

Patient Info: Adrienne, Female | Stage IV

Metastatic Site: Liver

As of June 2026, Adrienne had Stage IV colon adenocarcinoma with liver metastases, had experienced liver recurrence after intensive multimodal treatment, and was back on FOLFIRI plus Avastin.

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Stage IV Colorectal Cancer: Justine's Patient Story

Patient Info: Justine, Female, Under 40 | Stage IV

Metastatic Site: Liver

As of June 2026, Justine was living with Stage IV rectal cancer involving the liver after chemoradiation, major surgery, FOLFOX, and liver-directed local therapies.

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Stage IV Colorectal Cancer: Ken's Patient Story

Patient Info: Ken, Male, 50s | Stage IV

Metastatic Site: Liver

As of May 2026, Ken was more than 3 years into Stage IV colorectal cancer. He was not cancer-free or NED, but described the disease as minimal and manageable with surveillance, maintenance chemotherapy/targeted therapy, and occasional ablation.

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Stage IV Colorectal Cancer: Nathan's Survivor Story

Patient Info: Nathan, Male, Under 40 | Stage IV

Metastatic Site: Liver; peritoneal membrane

Declared tumor-free after aggressive treatment for Stage IV colon cancer, including colectomy, FOLFOX chemotherapy, and HIPEC, while continuing to live with treatment effects, an ileostomy, neuropathy, and scan anxiety.

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Three separate primary cancers: lung squamous carcinoma, gastric adenocarcinoma, and hepatocellular carcinoma

Patient Info: Anonymized, Male, 60s

Biomarkers: Multiple primaries: lung squamous markers CK5/6 and P40; gastric cancer HER2 negative; liver cancer markers hepatocyte/GPC3/HSP70/CD34.

As of May 2026, all 3 primary cancers were controlled: lung cancer had no recurrence after surgery, gastric cancer remained in sustained remission on sintilimab maintenance, and hepatocellular carcinoma was controlled after ablation; ECOG performance status was 1.

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Stage IV Colorectal Cancer: Helen's Survivor Story

Patient Info: Helen, Female, 40s | Stage IV

Metastatic Site: Liver; pelvis

No active tumors / no evidence of disease after liver-directed treatment, liver surgery/ablation, colon resection, and hysterectomy, though she personally described herself as living with cancer and still planned cleanup treatment.

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Small-cell lung cancer: envafolimab response complicated by immune-related diabetes, pneumonitis, and later submandibular progression

Patient Info: Anonymized, Male, 60s | Stage Metastatic/Advanced

Biomarkers: ProGRP and NSE were elevated at diagnosis. Tumor molecular biomarkers were not reported; diabetes antibodies were negative.

Metastatic Site: left submandibular region / adjacent lymph nodes

After initial partial response on envafolimab, carboplatin, etoposide, and thoracic radiotherapy, he developed immune-related diabetes, pneumonitis, and progressive left submandibular metastatic disease requiring iodine-125 seeds and later anlotinib.

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Stage IV Colorectal Cancer: David's Survivor Story

Patient Info: David, Male, Under 40 | Stage IV

Metastatic Site: Liver; lymph nodes near the heart

As of March 2026, David showed no evidence of cancer after Stage IV colorectal cancer with liver and near-heart lymph node metastases, following chemotherapy, tumor and lymph-node surgery, liver-directed radiation, radioembolization, and liver transplant.

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Recurrent lung cancer with malignant airway compression: Dumon Y-stent improved breathing

Patient Info: Anonymized, Female

Dumon Y-shaped airway stenting restored airway patency, improved left-lung perfusion from 13% to 59%, and reduced dyspnea from MMRC grade 3 to grade 1.

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Stage IV Colorectal Cancer: Mike's Patient Story

Patient Info: Mike Ray, Male, Under 40 | Stage IV

Biomarkers: Lynch syndrome

Metastatic Site: Liver

As of March 2026, Mike had recovered quickly from a May 2025 liver transplant after about 2.5 years of cancer-control treatment for liver-metastatic colon cancer with Lynch syndrome, and he had returned to running, weight training, and triathlon goals.

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Stage IV Colorectal Cancer: Kina's Survivor Story

Patient Info: Kina, Female | Stage IV

Metastatic Site: Lungs; lymph node

As of January 2026, Kina described herself as technically having no cancer/no evidence of disease after lung resections, though confirmatory CT was still pending and she was still recovering from complications.

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Stage IV Colorectal Cancer: Kristie's Patient Story

Patient Info: Kristie, Female, 50s | Stage IV

Metastatic Site: liver

Kristie is living with Stage IV colon cancer with liver recurrence, prior chemotherapy/radiation/surgery/ablation, and a planned liver resection option after second-opinion review.

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Stage IVA EGFR-mutated lung adenocarcinoma with malignant pleural effusion: stable disease on ivonescimab plus pemetrexed

Patient Info: Anonymized, Male, 50s | Stage IV

Biomarkers: EGFR exon 19 deletion persisted. Later pleural fluid had PD-L1 TPS 40% / CPS 41, low TMB

Metastatic Site: pleura / malignant pleural effusion

As of August 2025, Stage IVA EGFR-mutated lung adenocarcinoma with malignant pleural effusion was stable on ivonescimab plus pemetrexed after prior progression on gefitinib, almonertinib, and ivonescimab monotherapy.

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Stage IV KRAS-mutant colorectal cancer with bilobar liver metastases: multimodality treatment and no evidence of disease

Patient Info: Anonymized, Female, 40s | Stage IV

Biomarkers: KRAS-mutated; BRAF wild-type; mismatch repair proficient

Metastatic Site: liver

After second liver resection, follow-up MRI at 8 weeks showed continued response at the SABR site and no recurrent disease; she was receiving adjuvant capecitabine and remained well.

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Stage IIA ER/PR-positive mucinous breast cancer: tamoxifen plus cryoablation with no recurrence

Patient Info: Anonymized, Female, 70+ | Stage II

Biomarkers: ER/PR strongly positive, HER2 negative; CA15-3 and CEA remained normal during follow-up.

At approximately 32 months after cryoablation, the treated area had decreased to a less distinct 0.7 cm scar-like region, with no evidence of recurrence in either breast, axillae, or distant sites.

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Stage IVB ROS1-rearranged lung adenocarcinoma with bilateral ocular metastases: durable response to entrectinib

Patient Info: Anonymized, Male, 40s | Stage IV

Biomarkers: EZR-ROS1 fusion with mutation frequency 42.99%; TTF-1-positive in lung and left-eye tumor tissue

Metastatic Site: bilateral uveal/ocular metastases; bronchial lymph…

After about 3 years on entrectinib, systemic disease remained well controlled with partial remission, both eyes had best corrected visual acuity of 20/20, and no treatment-related discomfort or adverse events were reported.

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Triple-negative breast cancer history with later chest wall sarcomatoid carcinoma treated by embolization, ablation, and chemotherapy

Patient Info: Anonymized, Female, 40s

Biomarkers: Initial breast cancer was triple-negative. Later chest-wall lesion was weak ER-positive, PR/HER2-negative

By February 2025, the treated chest wall lesion had decreased to about 13 x 7 mm after embolization, radiofrequency ablation, and albumin-bound paclitaxel plus cisplatin, with no peripheral or distant metastatic foci seen.

PubMed CentralRead more →