Long-term complete response to targeted therapy for relapsed lung cancer with an EGFR mutation

This lung cancer diagnosis at a glance

Stage at diagnosis
Stage III
Subtype
Adenocarcinoma
Biomarkers
EGFR mutation
Sex
Female
Treatment
surgery, chemotherapy, radiation and targeted therapy
Outcome
Responding Well

Treatment course, step by step

  1. She had surgery to remove the left lung.
  2. She then completed 6 cycles of chemotherapy followed by radiation.
  3. After the cancer relapsed, she started gefitinib.
  4. She temporarily switched to erlotinib because gefitinib was unavailable, then resumed gefitinib.

What happened, in summary

A 47-year-old Syrian woman was diagnosed with Stage III adenocarcinoma of the left lung in March 2020. She had a complete pneumonectomy, followed by 6 cycles of chemotherapy and radiation. She then entered regular follow-up.

In January 2021, shortness of breath and cough led to new scans showing recurrent disease in the right lung. A new biopsy again confirmed adenocarcinoma, and testing found an EGFR mutation. She began gefitinib in February 2021. After 3 months, imaging showed a complete response.

Because gefitinib later became unavailable at her hospital, she switched to erlotinib for 9 months. During erlotinib treatment, her eyelashes became unusually long and required repeated trimming. She also experienced skin symptoms, dry skin, mild diarrhea, and loss of appetite. When gefitinib became available again, she resumed it and the eyelash changes resolved.

The three most recent imaging studies continued to show a complete response. Nearly 4 years after the relapse, she remained in good health without tumor progression. Her experience also reflects the challenge of maintaining cancer treatment when access to specific medicines is limited.

Where this story comes from

This is a lay summary of an account first published by PMC / PubMed Central. Read the original in full

How we source and attribute stories Accuracy and limitations

Collections this story belongs to

Similar lung cancer stories

These are lay summaries of published cancer stories, for information only. No two cancers behave the same way, and nothing here predicts your own diagnosis or replaces advice from your oncology team. Read the full disclaimer

Search more lung cancer stories