Mixed gastric neuroendocrine tumor and fundic-gland adenocarcinoma in autoimmune gastritis

This gastric cancer diagnosis at a glance

Subtype
Adenocarcinoma
Treatment
surgery
Outcome
Cancer-Free / NED

Treatment course, step by step

  1. Three months after diagnosis, the patient underwent laparoscopic subtotal gastrectomy because multiple tumors were close to the resection margins.

What happened, in summary

Pathology showed a rare mixed gastric tumor containing two distinct components: a well-differentiated grade 1 neuroendocrine tumor and a well-differentiated fundic-gland type adenocarcinoma. Both components had invaded into the submucosa, and the surrounding stomach showed autoimmune atrophic gastritis with intestinal metaplasia and neuroendocrine-cell hyperplasia.

Because there were multiple lesions and tumor tissue was close to the resection margins, the patient underwent laparoscopic subtotal gastrectomy three months after diagnosis. No residual tumor was found in the surgical specimen.

During subsequent regular follow-up, there were no signs of recurrence or metastasis, supporting a latest outcome of no evidence of disease. The case was also notable for autoimmune atrophic gastritis, which formed the background in which the mixed gastric tumors developed.

Where this story comes from

This is a lay summary of an account first published by PMC / PubMed Central. Read the original in full

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