Stage IV Colorectal Cancer: David's Patient Story

Patient Info: David, Male | Stage IV

Metastatic Site: Liver; lung; tailbone/bone

Had clear scans after multiple treatments for recurrent Stage IV colon cancer, but a later positive Signatera test suggested possible microscopic disease and more treatment was being planned.

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Stage IV Colorectal Cancer: Kalei's Patient Story

Patient Info: Kalei, Female | Stage IV

Metastatic Site: Lungs

Living with Stage IV rectal cancer after lung metastases were treated surgically; later imaging raised concern for possible recurrence in the lung and rectal area, but lymph-node biopsy was clear and further workup was ongoing.

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Stage IV Colorectal Cancer: David's Survivor Story

Patient Info: David, Male, Under 40 | Stage IV

Metastatic Site: Liver; lymph nodes near the heart

As of March 2026, David showed no evidence of cancer after Stage IV colorectal cancer with liver and near-heart lymph node metastases, following chemotherapy, tumor and lymph-node surgery, liver-directed radiation, radioembolization, and liver transplant.

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Stage IV Colorectal Cancer: Joe's Patient Story

Patient Info: Joe, Male | Stage IV

Biomarkers: Specific biomarkers not reported

Metastatic Site: Liver; lymph nodes; lungs

Stage IV colon cancer initially reached no evidence of disease after FOLFOX plus panitumumab, but later recurred in the liver and lymph nodes, progressed to the lungs, and did not respond to later FOLFOX rechallenge or FOLFIRI before he started an immunotherapy clinical trial.

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Stage IV Colorectal Cancer: Alyssa's Patient Story

Patient Info: Alyssa Kelly, Female, Under 40 | Stage IV

Metastatic Site: Liver; lung

More than 4 years after pregnancy-associated Stage IV colorectal cancer, Alyssa was alive with her son, but after more than 1 year off chemotherapy she had several lung tumors, restarted chemotherapy, and was looking into clinical trials.

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Stage IV Colorectal Cancer: Mike's Patient Story

Patient Info: Mike Ray, Male, Under 40 | Stage IV

Biomarkers: Lynch syndrome

Metastatic Site: Liver

As of March 2026, Mike had recovered quickly from a May 2025 liver transplant after about 2.5 years of cancer-control treatment for liver-metastatic colon cancer with Lynch syndrome, and he had returned to running, weight training, and triathlon goals.

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Three years without recurrence after intensive treatment for recurrent rectal cancer

Patient Info: Anonymized, Female, 50s | Stage IV

Biomarkers: pMMR; KRAS mutation; BRAF wild-type

Metastatic Site: peritoneum

No recurrence had been detected 3 years after the extensive surgery and intraoperative treatments.

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Stage IV Colorectal Cancer: Natasha's Patient Story

Patient Info: Natasha McCants, Female, 40s | Stage IV

Biomarkers: Unspecified tumor mutation identified by molecular testing

Metastatic Site: Liver; lungs; ovary

As of February 2026, Natasha’s Stage IV colorectal cancer was under control after mutation-informed treatment at City of Hope, but Signatera showed potentially active cells and she remained on daily chemotherapy pills.

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Stage IV Colorectal Cancer: Sydney's Patient Story

Patient Info: Sydney, Female | Stage IV

Metastatic Site: Liver; lungs

Sydney was living with Stage IV colorectal cancer involving the liver and lungs. After multiple lines of treatment, she had a new liver spot and was back on lower-dose FOLFIRI every other Tuesday with a 46-hour pump.

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Stage III Colorectal Cancer: John's Survivor Story

Patient Info: John Murray, Male, 50s | Stage III

As of February 2026, John’s latest tests showed no evidence of cancer after Stage III rectal cancer treatment, including chemotherapy, radiation, and laparoscopic surgery with permanent colostomy; close surveillance was planned for 2 years.

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Joe Carr

Patient Info: Joe Carr | Stage IV

Metastatic Site: liver, lungs

After about 2.5 years of chemotherapy and radiation, Joe had progression in his liver and lungs and was preparing to move into a clinical trial.

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Stage IV Colorectal Cancer: Cora's Patient Story

Patient Info: Cora, Female | Stage IV

Metastatic Site: Liver; lungs

As of February 2026, Cora had recurrent Stage IV colorectal cancer with a positive ctDNA test but clear CT imaging after stopping an immunotherapy trial because of toxicity, so ongoing care and monitoring were still needed.

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I Survived Childhood Cancer. Then I Was Diagnosed AGAIN at 18.

Patient Info: Maria, Female, Under 40

Biomarkers: Mosaic variegated aneuploidy syndrome 3; prior colon polyp genetic testing negative before final diagnosis

The early colon cancer was removed during colonoscopy, but Maria continues long-term surveillance for recurrent polyps and survivorship effects related to childhood Wilms tumor and MVA3.

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Stage IV Colorectal Cancer: Kristie's Patient Story

Patient Info: Kristie, Female, 50s | Stage IV

Metastatic Site: liver

Kristie is living with Stage IV colon cancer with liver recurrence, prior chemotherapy/radiation/surgery/ablation, and a planned liver resection option after second-opinion review.

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Stage IV Colorectal Cancer: Scott's Survivor Story

Patient Info: Scott Zeff, Male, 60s | Stage IV

As of January 2026, Scott had finished treatment for Stage IV rectal cancer, the cancer had not spread to other areas, and he was recovering with a temporary ileostomy while moving forward cancer-free.

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Stage IV Colorectal Cancer: Kayleigh's Patient Story

Patient Info: Kayleigh, Female | Stage IV

Metastatic Site: right lung

Kayleigh remained in active treatment for Stage IV colorectal cancer with curative intent; the right-lung nodule and other disease were described as shrinking considerably.

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Colorectal Cancer: Donna's Survivor Story

Patient Info: Donna Marie Caruso, Female, 70+

As of November 2025, Donna was in rectal cancer survivorship after surgery, radiation and chemotherapy, with improved quality of life through support for low anterior resection syndrome; no formal stage or NED status was stated.

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Stage IV KRAS-mutant colorectal cancer with bilobar liver metastases: multimodality treatment and no evidence of disease

Patient Info: Anonymized, Female, 40s | Stage IV

Biomarkers: KRAS-mutated; BRAF wild-type; mismatch repair proficient

Metastatic Site: liver

After second liver resection, follow-up MRI at 8 weeks showed continued response at the SABR site and no recurrent disease; she was receiving adjuvant capecitabine and remained well.

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The Cancer Spread One Year Later…

Patient Info: Kalei, Female, Under 40 | Stage IV

Metastatic Site: Lungs; bilateral lung nodules

Kalei initially had Stage II rectal cancer that responded to chemoradiation and IV chemotherapy without rectal surgery. In 2025, biopsy-proven lung metastasis changed the diagnosis to Stage IV. As of October 2025, she had undergone lung resections with clear margins and remained in ongoing follow-up rather than having a clearly stated NED status.

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Stage III Colorectal Cancer: Kara's Survivor Story

Patient Info: Kara Lionetta, Female | Stage III

An update to Kara's story reported that she was no evidence of disease while completing cleanup chemotherapy and planning later ileostomy reversal.

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Stage IV Colorectal Cancer: Claire's Patient Story

Patient Info: Claire, Female, 40s | Stage IV

Metastatic Site: Abdominal wall; lungs

As of September 2025, Claire was living with metastatic recurrent colorectal cancer as a chronic illness, receiving chemotherapy every 2 weeks since April 2018, approaching her 200th round, and maintaining stable disease with no signs of growth.

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Colorectal Cancer: Shiva's Survivor Story

Patient Info: Shiva Sharma, Male, 40s

As of September 2025, Shiva described being told he was cancer-free after surgery and continued follow-up with scans every 6 months and regular colonoscopy.

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Metastatic rectal cancer: total scapulectomy improves pain and function

Patient Info: Anonymized, Male, 40s | Stage IV

Biomarkers: CEA 418 ng/mL preoperatively; 10.3 ng/mL postoperatively; 7.2 ng/mL at 7 months; 11.1 ng/mL at about 5 months postoperatively; 6.4 ng/mL at 8 months

Metastatic Site: liver, right acromion/scapula, left adrenal gland

The patient had meaningful pain relief and functional recovery after total scapulectomy, but later developed liver and left adrenal progression and remained on palliative chemotherapy with a positive response.

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Colorectal Cancer: Kathy's Survivor Story

Patient Info: Kathy Ball-Toncic, Female, 60s

As of August 2025, Kathy had been declared cancer-free again in August 2024 after treatment for breast DCIS and a later colorectal cancer, rebuilt strength with physical therapy, and completed a 162-mile Pan-Mass Challenge ride.

Dana-FarberRead more →