Rectal Signet Ring Cell Cancer With Rapid, Unusual Metastatic Spread

Patient Info: Anonymized, Male, Under 40 | Stage Metastatic/Advanced

Metastatic Site: peritoneum|lumbosacral vertebrae|bone marrow|right…

The cancer recurred 3 months after surgery and spread rapidly to the peritoneum, bones, bone marrow, orbit, and skin. He later entered palliative care.

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Metastatic Colorectal Cancer Treatment Complicated by Severe Lung Inflammation

Patient Info: Anonymized, Male, 70+ | Stage IV

Biomarkers: KRAS wild type; NRAS wild type

Metastatic Site: liver

He recovered from the severe treatment-related lung inflammation, was weaned off oxygen within 1 month, and continued oncology follow-up while living with Stage IV colorectal cancer.

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Stage IV Colorectal Cancer: Anatole's Survivor Story

Patient Info: Anatole Karpovs, Male, Under 40 | Stage IV

Metastatic Site: Liver

As of October 2018, Anatole had no evidence of disease after liver surgery and FOLFIRI for a July 2014 liver recurrence, and had been cancer-free for almost 4 years while recognizing that microscopic disease could still be possible.

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Locally advanced transverse colon cancer complicated by a colocutaneous fistula

Patient Info: Anonymized, Female, 60s | Stage III

After initially recovering from surgery, she developed a respiratory infection, sepsis and metabolic encephalopathy and died after cardiorespiratory arrest on postoperative day 12.

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Severe but reversible neurologic side effects during 5-fluorouracil treatment for Stage IV colorectal cancer

Patient Info: Anonymized, Male, 60s | Stage IV

Metastatic Site: liver

His confusion, dysarthria and ataxia resolved within 24 hours with intravenous hydration, and the MRI lesion resolved within 1 month. The cancer later progressed on restaging, prompting another treatment change.

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Stage III Colon Cancer Found Alongside Ovarian and Adrenal Cancers

Patient Info: Anonymized, female, 40s | Stage III

More than 2 years after diagnosis, she had no sites of recurrence or metastatic disease, and a recent colonoscopy showed no recurrence or polyps.

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Metastatic Colon Cancer With Tumor Thrombus Extending Into the Right Atrium

Patient Info: Anonymized, female, 40s

Biomarkers: BRAF wild-type, KRAS wild-type, NRAS wild-type

Her metastatic colorectal cancer progressed despite multiple treatment lines. Supportive care alone was chosen after her performance status deteriorated, and she later died from multiorgan failure in the setting of metastatic cancer.

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Stage III Rectal Cancer Among Five Synchronous Gastrointestinal Cancers

Patient Info: Anonymized, male, 50s | Stage III

Six years after surgery and adjuvant treatment, he remained without recurrence or metastasis and continued regular follow-up.

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Stage IV Colorectal Cancer: Dawn's Survivor Story

Patient Info: Dawn Eicher, Female, Under 40 | Stage IV

Metastatic Site: liver

After treatment for Stage IV colorectal cancer and a later recurrence, Dawn had 2 consecutive scans showing no evidence of disease and had been cancer-free for 8 months.

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Sigmoid colon cancer: complete response after repeated metastatic recurrences and multimodal therapy

Patient Info: Anonymized, Male, 60s | Stage IV

Biomarkers: KRAS/NRAS/BRAF status not reported; CEA elevation used for recurrence monitoring

Metastatic Site: left lung, mediastinal lymph nodes, left adrenal…

By 2011, all metastatic lesions had achieved complete response; nearly 1 year after the last adrenal irradiation, no recurrence had been detected.

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Stage III sigmoid colon invasive micropapillary carcinoma treated with sigmoidectomy and modified FOLFOX6

Patient Info: Anonymized, Male, 70+ | Stage III

Biomarkers: CEA normal; CA 19-9 normal; MUC1 inside-out staining pattern in micropapillary component

After diagnostic endoscopic resection, sigmoidectomy with regional lymph node resection, and 6 cycles of modified FOLFOX6, he was in good condition with no evidence of recurrence 12 months after surgery.

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Sigmoid colon cancer with later inguinal lymph-node metastasis: surgery, FOLFOX, FOLFIRI, and cetuximab

Patient Info: Anonymized, Male, 60s | Stage IV

Biomarkers: CEA was elevated at diagnosis and recurrence. Metastatic lymph node was CK20 positive/CK7 negative; EGFR mutation status not reported.

Metastatic Site: left inguinal lymph node

Apparently disease-free 8 months after surgical removal of the left inguinal lymph-node metastasis followed by FOLFIRI plus cetuximab.

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