HER2-Positive Recurrent Breast Cancer Treated With Multiple Targeted and Local Therapies

Patient Info: Anonymized, female, 50s | Stage IV

Biomarkers: 2008 recurrence: ER 80%, HER2 FISH amplified. 2011 recurrence: ER 80%

Metastatic Site: liver, skin

After 25 cycles of eribulin, treatment was still ongoing; nodal disease remained stable, while later imaging also noted new metabolic activity in the upper lung.

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Stage IV Breast Cancer: Lindsey's Patient Story

Patient Info: Lindsey Ballas, Female | Stage IV

Metastatic Site: Not reported

As of September 2017, Lindsey was living with Stage IV metastatic breast cancer on advanced targeted maintenance therapy every 3 weeks, with stable disease and continued work and family life.

Cleveland ClinicRead more →

HER2-Positive Inflammatory Breast Cancer: Trish's Patient Story

Patient Info: Trish Vickery, female, 50s

Biomarkers: HER2-positive

At 58, Trish was living an active life after treatment, including working, traveling, exercising, and rowing.

Dana-FarberRead more →

Breast cancer survivor finds comfort in quilting community

Patient Info: Michelle Hines, female

Michelle had been cancer-free since November 2015 at the time of the story.

MD AndersonRead more →

Stage IV HER2-Positive Breast Cancer: Sarah's Patient Story

Patient Info: Sarah, Female, Under 40 | Stage IV

Biomarkers: HER2-positive; BRCA and other known hereditary breast cancer genes not identified in family history discussion

As of January 2017, Sarah had been living for almost 3 years with recurrent Stage IV HER2-positive breast cancer and was receiving Kadcyla every 3 weeks.

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Stage IV Breast Cancer: Debora's Patient Story

Patient Info: Debora, Female, 60s | Stage IV

Debora was living with metastatic breast cancer after Stage III disease treated with surgery, chemotherapy, radiation therapy, and targeted therapy; four years after surgery, she was told the cancer had metastasized and was on targeted therapy.

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Stage III Inflammatory Breast Cancer Diagnosed After Severe Breast Pain and Swelling Following Mammography

Patient Info: Anonymized, female, 60s | Stage IV

Biomarkers: ER negative, PR negative, HER2 highly positive

After later metastatic disease was found, she chose no further active treatment and died of progressive disease in 2012.

PubMed CentralRead more →

HER2-Positive Right Breast Cancer With Complete Response Before Bilateral Mastectomy

Patient Info: Anonymized, female, 50s

Biomarkers: ER negative, PR negative, HER2 positive

After neoadjuvant treatment, imaging showed complete resolution of the right-breast mass and mastectomy pathology found no residual right-breast tumor or malignant right sentinel node.

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Stage IV Breast Cancer: Liu's Patient Story

Patient Info: Liu Jing | Stage IV

More than eight years after a stage 4 diagnosis, Liu Jing remained on hormone and targeted therapies and continued working, walking, and mountain hiking.

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Recurrent HER2-amplified breast cancer: complete remission on trastuzumab-based therapy

Patient Info: Anonymized, Female, 40s | Stage Metastatic/Advanced

Biomarkers: Primary tumor was ER/PR negative and HER2 not amplified. Recurrent lymph-node disease became ER/PR positive and HER2 amplified by FISH.

Metastatic Site: left axillary and infraclavicular lymph nodes

After HER2-amplified nodal recurrence, paclitaxel plus trastuzumab produced complete clinical remission; she continued trastuzumab monotherapy with tolerable neuropathy.

PubMed CentralRead more →

Stage IV Breast Cancer: Su's Patient Story

Patient Info: Su Chiao | Stage IV

Metastatic Site: bones, thymus, liver

After 7 years, the breast cancer had spread to the bones and thymus, and more recently it spread to the liver, where she underwent embolization.

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