Bilateral Breast Cancers Followed by Metastatic Disease and Long Eribulin Treatment

Patient Info: Anonymized, female, 50s | Stage IV

Biomarkers: Left primary: ER 90%, HER2 FISH not amplified, Ki67 25%. Right primary: ER 90%

Metastatic Site: lung, pleura, liver, bone

After pelvic bone metastases appeared in 2017, she stopped eribulin, received pelvic radiation and remained on fulvestrant treatment.

PubMed CentralRead more →

Metastatic Breast Cancer With Durable Liver and Peritoneal Response to Eribulin

Patient Info: Anonymized, female, 50s | Stage IV

Biomarkers: Initial tumor: ER 90%, PgR 70%. Liver metastasis: ER 60%, HER2 1+

Metastatic Site: liver, peritoneum

While continuing eribulin beyond 34 cycles, her liver disease was stable and the peritoneal response persisted after earlier major tumor reduction.

PubMed CentralRead more →

Metastatic Breast Cancer With Brain, Bone, Lung and Liver Disease Responding During Eribulin Treatment

Patient Info: Anonymized, female, 40s | Stage IV

Biomarkers: Initial tumor: ER 90%, HER2 negative, Ki67 10%. Lung metastasis: ER 90%

Metastatic Site: lung, bone, brain, liver

Eribulin remained ongoing with reduced brain lesions, stable bone disease and continued shrinkage of liver metastases after prior systemic progression.

PubMed CentralRead more →

Breast cancer returning 21 years later as a solitary parotid metastasis

Patient Info: Anonymized, Female, 70+ | Stage IV

Biomarkers: Parotid metastasis ER positive; PR positive; HER2 borderline by IHC but FISH 1.82

Metastatic Site: left parotid gland

More than 5 months after the parotid metastasis was diagnosed, the tumour had slightly decreased in size and her metastatic disease remained stable on endocrine therapy.

PubMed CentralRead more →

Breast cancer returning years later in the biceps muscle

Patient Info: Anonymized, Female, 60s | Stage IV

Biomarkers: ER positive

Metastatic Site: left biceps muscle

Her arm symptoms improved considerably after radiotherapy, and MRI 6 months later showed a significant decrease in the size of the biceps tumour.

PubMed CentralRead more →

Metastatic lobular breast cancer to bladder trigone: partial response to tamoxifen

Patient Info: Anonymized, Female, 60s | Stage IV

Biomarkers: progesterone receptor-positive; genetic testing including BRCA1 negative

Metastatic Site: bladder trigone

As of January 2012, urge incontinence had resolved and PET showed decreased activity in the breast and bladder trigone lesions nearly 10 months after starting tamoxifen, consistent with clinical and partial radiologic remission.

PubMed CentralRead more →

Lobular breast cancer with extraocular muscle and lung metastases: ocular improvement after radiotherapy and tamoxifen

Patient Info: Anonymized, Female, 60s | Stage IV

Biomarkers: Original breast cancer: ER-negative; PR-negative. Extraocular muscle metastasis/recurrent disease: ER strongly positive; PR strongly positive.

Metastatic Site: bilateral extraocular muscles, right upper lobe lung,…

At 18 months after presentation with extraocular muscle metastases, PET showed no abnormality, diplopia had resolved, and ocular motility had markedly improved, with mild bilateral ptosis remaining.

PubMed CentralRead more →