Trastuzumab for HER2 Positive Breast Cancer: 78 Real Stories

78 stories match breast cancer, HER2 positive and trastuzumab. 77 of them mention targeted therapy.

Cancer Stories

Anne, who was diagnosed with Stage IV Breast CancerBreast Cancer

Stage IV HER2-Positive Breast Cancer: Anne's Patient Story

Patient Info: Anne Keane, 40s | Stage IV

Biomarkers: HER2-positive

Metastatic Site: bones, liver

Anne had an extraordinary response to first-line treatment for metastatic HER2-positive breast cancer and remained on the same HER2-targeted therapy for 6 years.

Dana-Farber
OutcomeResponding Well
A patient, who was diagnosed with Stage I Breast CancerBreast Cancer

Stage I ER-positive/HER2-positive breast cancer with radiation-associated morphea

Patient Info: Anonymized, Female, 70+ | Stage I

Biomarkers: ER-positive; PR-negative; HER2-positive

No evidence of breast cancer recurrence after 2018 treatment; ongoing issue was generalized morphea and breast deformity related to prior radiation, improved with mycophenolate by April 2024.

PubMed Central
OutcomeCancer-Free / NED
A patient, who was diagnosed with Stage IV Breast CancerBreast Cancer

HER2-Positive Breast Cancer With Metastatic Progression and Drug-Induced Lupus During T-DM1

Patient Info: Anonymized, Female, 50s | Stage IV

Biomarkers: ER-positive, PR-negative, HER2-positive

Metastatic Site: bones, axillary lymph nodes, intra-abdominal lymph…

More than 5 years after her March 2018 diagnosis, she was living with metastatic breast cancer, but T-DM1 had been stopped after disease progression in 2023.

PubMed Central
OutcomeSetback / Progression
A patient, who was diagnosed with Stage II Breast Squamous Cell CarcinomaBreast Cancer

HER2-positive squamous cell breast cancer in complete remission

Patient Info: Anonymized, Female, 40s | Stage II

Biomarkers: HER2-positive squamous cell breast cancer, ER/PR negative, PD-L1 negative

Clinical complete remission and survival beyond 4 years after mastectomy, AC-TH chemotherapy, and HER2-directed maintenance therapy for Stage IIA HER2-positive primary squamous cell breast cancer.

PubMed Central
OutcomeCancer-Free / NED
A patient, who was diagnosed with Stage IV Invasive Ductal CarcinomaBreast Cancer

Severe Corneal Injury After Trastuzumab for Metastatic HER2-Positive Breast Cancer

Patient Info: Anonymized, Female, 50s | Stage IV

Biomarkers: ER-positive, PR-positive, HER2-positive

Metastatic Site: lungs, spine, left adrenal gland, calvarium, orbit,…

She was living with widespread metastatic breast cancer when trastuzumab was stopped because of severe eye toxicity.

PubMed Central
OutcomeLiving With Cancer
A patient, who was diagnosed with Stage IV Breast CancerBreast Cancer

HER2-Positive Breast Cancer That Spread to the Cervix

Patient Info: Anonymized, female, 60s | Stage IV

Biomarkers: HER2-positive; ER and PR less than 1% in the left breast tumor

Metastatic Site: cervix, esophagus, mediastinal lymph nodes

Cervical metastasis showed a local complete response after brachytherapy, but systemic disease later progressed to the esophagus. She died after 4 months of nutritional support and palliative treatment.

PubMed Central
OutcomeIn Memory
A patient, who was diagnosed with Stage IV Invasive Ductal CarcinomaBreast Cancer

Stage 4 invasive ductal carcinoma: metastatic disease with bone involvement managed successfully

Patient Info: Anonymized, Female, 50s | Stage IV

Biomarkers: ER <1%; PR 0%; HER2 score 3+; Ki-67 60%

Metastatic Site: bone (12th thoracic vertebra/T12)

Stage IV HER2-positive breast cancer had improved T12 bone metastasis, major breast-tumor regression on trastuzumab deruxtecan, and pathologic complete response in the breast after mastectomy; durable systemic disease status was not reported.

PubMed Central
OutcomeResponding Well
A patient, who was diagnosed with Stage I Invasive Ductal CarcinomaBreast Cancer

HER2-positive breast cancer: surgery after neoadjuvant therapy

Patient Info: Anonymized, Female, 60s | Stage I

Biomarkers: ER 1% weakly positive; PR-negative; HER2-positive

No evidence of disease on follow-up while taking anastrozole after pathologic complete response to neoadjuvant T-DM1, lumpectomy/SLNB, radiotherapy, and adjuvant trastuzumab for Stage I HER2-positive breast cancer.

PubMed Central
OutcomeCancer-Free / NED
A patient, who was diagnosed with Breast CancerBreast Cancer

HER2-positive apocrine breast cancer: chemotherapy and Herceptin

Patient Info: Anonymized, Female, 60s

Biomarkers: HER2-positive; AR-positive; ER-negative; PR-negative

Disease-free for 2 years after treatment for HER2-positive apocrine breast cancer, with no reported lymph-node recurrence or distant metastases during surveillance.

PubMed Central
OutcomeCancer-Free / NED
Allison, who was diagnosed with Stage II Invasive Ductal CarcinomaBreast Cancer

Stage II HR-Positive Invasive Ductal Carcinoma: Allison's Patient Story

Patient Info: Allison Tierney, Female | Stage II

Biomarkers: ER-positive; PR-positive; HER2-positive; CHEK2 mutation; BRCA1/2 negative

As of March 2024, Allison had completed Taxol and Herceptin treatment, was on tamoxifen planned for 10 years, and had moved to 6-month oncology follow-up. No metastatic disease or recurrence was reported.

YouTube — The Patient Story
OutcomeCare Ongoing
A patient, who was diagnosed with Stage IV Invasive Ductal CarcinomaBreast Cancer

Metastatic HER2-Positive Breast Cancer With Treatment-Related Telangiectasias

Patient Info: Anonymized, female, 60s | Stage IV

Biomarkers: HER2-positive; initially ER-negative and PR-negative; metastatic disease weakly ER-positive and PR-negative; germline testing negative

Metastatic Site: left supraclavicular, mediastinal, axillary and…

Living with HER2-positive breast cancer for 9+ years since her 2014 diagnosis, including metastatic disease since 2017. She remained on reduced-dose tucatinib in 2023 while treatment-related telangiectasias improved after dose reduction and electrocautery.

PubMed Central
OutcomeLiving With Cancer
A patient, who was diagnosed with Breast CancerBreast Cancer

HER2-Positive Mucoepidermoid Breast Cancer With 61 Months Without Recurrence

Patient Info: Anonymized, female, 50s

Biomarkers: HER2-positive; ER low expression; PR-negative

She was alive without signs of recurrence after 61 months of follow-up, providing just over 5 years of documented follow-up for this second primary breast cancer.

PubMed Central
OutcomeCancer-Free / NED
A patient, who was diagnosed with Stage I Breast CancerBreast Cancer

Five Years Without Breast Cancer Recurrence Despite a Markedly Elevated CA 15-3

Patient Info: Anonymized, female, 70+ | Stage I

Biomarkers: ER-positive, PR-positive, HER2-positive

Five years after her Stage I breast-cancer diagnosis, breast imaging and systemic evaluation showed no evidence of recurrence. The markedly elevated CA 15-3 was traced to a separate renal tumor and normalized after nephrectomy.

PubMed Central
OutcomeCancer-Free / NED
A patient, who was diagnosed with Stage IV Breast CancerBreast Cancer

Metastatic breast cancer: three years in remission with T-DM1 (Kadcyla) treatment

Patient Info: Anonymized, Female | Stage IV

Biomarkers: HER2-positive; hormone receptor-positive

Metastatic Site: liver; spine / bone

T-DM1 produced a complete clinical and radiological response after 7 cycles, sustained for 41 months and 60 cycles while treatment continued.

PubMed Central
OutcomeComplete Response
Olivia, who was diagnosed with Stage IV Inflammatory Breast CancerBreast Cancer

Stage IV HER2-Positive Inflammatory Breast Cancer: Olivia's Survivor Story

Patient Info: Olivia Franz, Female, Under 40 | Stage IV

Biomarkers: HER2-positive

Metastatic Site: Bones; distant lymph nodes

As of October 2023, Olivia continued to show no evidence of disease on scans while receiving maintenance trastuzumab and pertuzumab every 3 weeks and zoledronic acid every 3 months for bone health.

MD Anderson
OutcomeCancer-Free / NED