Inflammatory Breast Cancer and Dermatomyositis Improve Together With Treatment

Patient Info: Anonymized, female, 70+

Biomarkers: ER-positive, PR-positive, HER2-positive

When her dermatomyositis symptoms later worsened, CT, breast ultrasound and bone scans found no breast-cancer recurrence.

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Stage II HR-Positive Breast Cancer: Becki's Patient Story

Patient Info: Becki, Female, 40s | Stage II

Biomarkers: ER-positive; PR-positive; HER2-positive

As of 2023, Becki was receiving ongoing treatment for Stage II triple-positive breast cancer after recently completing mastectomy and experiencing chemotherapy-related fatigue, hair loss, and chemo fog.

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Metastatic Breast Cancer Treatment Caused Severe Circulation Problems in Her Fingers and Toes

Patient Info: Anonymized, Female | Stage IV

Biomarkers: HER2-positive; ER-negative; PR-negative

The digital ischaemia improved after gemcitabine was stopped, without revascularisation, debridement or amputation, although a small necrotic fingertip area persisted at 3 months. Metastatic breast cancer treatment continued with further systemic lines after progression.

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HER2-Positive Breast Cancer: Feyama's Survivor Story

Patient Info: Feyama Ashby, Female

Biomarkers: HER2-positive

As of September 2022, Feyama had completed chemotherapy, lumpectomy with lymph-node removal, reconstruction, and 6 weeks of VMAT radiation, and was entering close monitoring for 5 years before survivorship clinic follow-up.

MD AndersonRead more →

Cancer in Accessory Breast Tissue Under Both Arms in a Man

Patient Info: Anonymized, Male

Biomarkers: Left tumor: HER2-positive by gene amplification; ER-negative; PR-negative; Ki-67 70%; p53 staining 80%

After surgery removed both accessory-breast cancers, he continued with adjuvant paclitaxel, trastuzumab and radiation.

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HER2-Positive Breast Cancer: Tamara's Patient Story

Patient Info: Tamara, Female, Under 40

Biomarkers: HER2-positive

As of April 2022, Tamara was 4 years from HER2-positive breast cancer treatment and still in periodic follow-up before reaching the 5-year mark after treatment.

Stage II HER2-Positive Breast Cancer: María's Survivor Story

Patient Info: María Ángeles, Female | Stage II

Biomarkers: HER2-positive

As of March 2022, María Ángeles was 4 years from diagnosis after completing 14 chemotherapy sessions, mastectomy with immediate reconstruction, 21 radiation sessions, and trastuzumab for Stage II HER2-positive breast cancer.

Stage IV HER2-Positive Breast Cancer: Loli's Patient Story

Patient Info: Loli, Female, 60s | Stage IV

Biomarkers: HER2-positive

Metastatic Site: Liver

As of March 2022, Loli was living with HER2-positive metastatic breast cancer involving the liver and receiving clinical-trial treatment with chemotherapy every 21 days.

Rare HER2-positive mucinous cystadenocarcinoma of the breast

Patient Info: Anonymized, Female, 60s

Biomarkers: HER2-positive; ER-negative; PR-negative

She remained on systemic chemotherapy at the latest documented point, 6 months after starting treatment.

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Stage I HER2-Positive Invasive Ductal Carcinoma: Tammy's Patient Story

Patient Info: Tammy, Female | Stage I

Biomarkers: HER2-positive; triple-positive breast cancer

As of September 2021, this story segment described the start of Tammy’s adjuvant treatment plan after HER2-positive, triple-positive Stage I invasive ductal carcinoma was found; no later outcome was stated in this record.

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HER2-Positive Breast Cancer: Joy's Survivor Story

Patient Info: Joy Albi

Biomarkers: HER2-positive

Joy was in complete remission after the breast tumor was removed and she completed systemic chemotherapy.

Dana-FarberRead more →

Primary small-cell neuroendocrine breast cancer treated with mastectomy

Patient Info: Anonymized, Female, 40s

Biomarkers: ER-negative; HER2 not overexpressed; Ki-67 90%; synaptophysin-positive; chromogranin A-positive; TTF-1-positive.

Her postoperative recovery was uncomplicated, and she was referred for adjuvant oncology after chemotherapy and radiation were recommended.

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HER2-positive left breast cancer treated with trastuzumab and mastectomy

Patient Info: Anonymized, Female, 60s | Stage Metastatic/Advanced

Biomarkers: ER-negative; PR-negative; HER2/CerbB2 strongly positive; BRCA1/2 negative for known pathogenic variants; FANCA variant of uncertain significance.

She remained alive, asymptomatic, and disease-free while undergoing annual surveillance after treatment for the left HER2-positive breast cancer.

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Recovery from severe bowel and oesophageal complications after breast cancer chemotherapy

Patient Info: Anonymized, Female, 40s

Biomarkers: HER2-positive.

She regained independence after an 89-day hospital course, but breast surgery remained deferred three months after intensive-care discharge and tamoxifen was being used during recovery.

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A durable response to trastuzumab in heavily pretreated metastatic breast cancer

Patient Info: Anonymized, Female, 60s | Stage IV

Biomarkers: Initial tumor ER-positive and PR-positive. Metastatic liver biopsy ER-negative and PR-negative with HER2 IHC 1+ and nonamplified. Later biopsy ER and PR weakly positive at 5%–10%, HER2 IHC 1+ and nonamplified, and ERBB3 p. with evidence of HER2/HER3 pathway activation.

Metastatic Site: lungs; hilar and mediastinal lymph nodes; liver; bone

She had ongoing benefit for more than 10 months on trastuzumab and capecitabine, with improved symptoms, lower tumor markers, and a confirmed partial response.

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Stage I HER2-Positive Breast Cancer: Betty's Survivor Story

Patient Info: Betty, Female, 50s | Stage I

Biomarkers: HER2-positive

As of 2021, Betty was in remission after mastectomy and chemotherapy with Herceptin, while managing side effects such as hair loss, peripheral neuropathy, and weight changes.

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Stage II HR-Positive Breast Cancer: Faith's Survivor Story

Patient Info: Faith, Female, Under 40 | Stage II

Biomarkers: ER-positive; HER2-positive

Faith moved into survivorship after treatment for Stage II ER-positive, HER2-positive breast cancer, with ongoing fear of recurrence but renewed focus on family, nutrition, exercise, and work.

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Stage II HER2-Positive Breast Cancer: Kelsey's Survivor Story

Patient Info: Kelsey, Female, 40s | Stage II

Biomarkers: HER2-positive

Kelsey survived Stage II HER2-positive breast cancer after mastectomy, chemotherapy, and targeted therapy, with recovery supported by nutrition changes, massages, supplements, and support-group connection.

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HER2-positive breast cancer diagnosed during pregnancy and later spread to bone and brain

Patient Info: Anonymized, Female, Under 40 | Stage IV

Biomarkers: Initial tumour: ER 0%, PR <1%, HER2 3+

Metastatic Site: bone (L3)|brain

After treatment and surveillance without new lesions, she developed a large symptomatic occipital brain metastasis 14 months after completing paclitaxel and radiation and died after rapid neurological deterioration.

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HER2-Positive Breast Cancer Linked to a Rare Immune-Related Neurological Syndrome

Patient Info: Anonymized, Female, 40s

Biomarkers: HER2-positive in both foci; one focus ER-negative/PR-positive with Ki-67 45%; second focus ER-negative/PR-negative with Ki-67 35%; anti-Yo antibodies positive in serum and CSF; tumour-susceptibility gene panel negative

At 1 year, she had completed trastuzumab, continued tamoxifen, and had no evidence of recurrent breast cancer; intensive rehabilitation improved her mobility, although balance and right-sided neurological deficits persisted.

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Heart Failure and Electrical Conduction Changes During Trastuzumab Treatment

Patient Info: Anonymized, Female, 70+

Biomarkers: HER2-positive; ER-positive

Trastuzumab was suspended after acute heart failure and electrical conduction abnormalities; 4 weeks later, left ventricular function recovered and the ECG returned to normal during cardio-oncology follow-up.

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Fatal Bowel Infection After the First Chemotherapy Cycle for Early HER2-Positive Breast Cancer

Patient Info: Anonymized, Female, 70+

Biomarkers: ER-positive; PR-positive; HER2-amplified

Nine days after the first TCH cycle, she developed fulminant febrile neutropenia and Clostridium septicum sepsis with extensive bowel ischaemia; despite emergency treatment and resuscitation, she died 4 hours after hospital arrival.

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Occult breast cancer found in the axillary lymph nodes during diagnosis of four cancers

Patient Info: Anonymized, Female, 70+

Biomarkers: ER 90% positive; HER2 overexpression; CK19-positive; mammaglobin-positive.

Almost four years after the synchronous cancer diagnoses, she was alive without recurrence and continued letrozole and oncology follow-up.

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Stage IV HER2-Positive Breast Cancer: Christine's Survivor Story

Patient Info: Christine Hodgdon, Female, Under 40 | Stage IV

Biomarkers: HER2-positive

Christine had no evidence of disease after 1 year and continued HER2-targeted treatment with regular surveillance scans.