HER2 Positive Breast Cancer: 138 Real Stories

138 stories match breast cancer and HER2 positive. 123 of them mention chemotherapy.

Cancer Stories

A patient, who was diagnosed with Stage IV Invasive Ductal CarcinomaBreast Cancer

Stage 4 invasive ductal carcinoma: metastatic disease with bone involvement managed successfully

Patient Info: Anonymized, Female, 50s | Stage IV

Biomarkers: ER <1%; PR 0%; HER2 score 3+; Ki-67 60%

Metastatic Site: bone (12th thoracic vertebra/T12)

Stage IV HER2-positive breast cancer had improved T12 bone metastasis, major breast-tumor regression on trastuzumab deruxtecan, and pathologic complete response in the breast after mastectomy; durable systemic disease status was not reported.

PubMed Central
OutcomeResponding Well
A patient, who was diagnosed with Stage I Invasive Ductal CarcinomaBreast Cancer

HER2-positive breast cancer: surgery after neoadjuvant therapy

Patient Info: Anonymized, Female, 60s | Stage I

Biomarkers: ER 1% weakly positive; PR-negative; HER2-positive

No evidence of disease on follow-up while taking anastrozole after pathologic complete response to neoadjuvant T-DM1, lumpectomy/SLNB, radiotherapy, and adjuvant trastuzumab for Stage I HER2-positive breast cancer.

PubMed Central
OutcomeCancer-Free / NED
A patient, who was diagnosed with Stage I Invasive Ductal CarcinomaBreast Cancer

HER2-positive Stage I breast cancer: residual microinvasion after neoadjuvant T-DM1

Patient Info: Anonymized, Female, 70+ | Stage I

Biomarkers: ER-negative; PR-negative; HER2-positive

No evidence of disease on follow-up after neoadjuvant T-DM1, lumpectomy/SLNB showing only residual microinvasion/DCIS, continued adjuvant T-DM1 to 17 total cycles, and 52.5 Gy radiotherapy.

PubMed Central
OutcomeCancer-Free / NED
A patient, who was diagnosed with Stage IV Invasive Ductal CarcinomaBreast Cancer

BRCA2-mutant metastatic breast cancer: complete response with rucaparib maintenance

Patient Info: Anonymized, Female, Under 40 | Stage IV

Biomarkers: Germline BRCA2 mutation; somatic BRCA2 mutation; HER2 amplification not seen by FISH; grade III IDC

Metastatic Site: bone

She maintained a complete response for 2 years on rucaparib, letrozole, and zoledronic acid after upfront metastatic BRCA2-mutated breast cancer involving bone, axillary nodes, and right-breast nodules.

PubMed Central
OutcomeCancer-Free / NED
Irasema, who was diagnosed with Breast CancerBreast Cancer

HER2-Positive Breast Cancer: Irasema's Survivor Story

Patient Info: Irasema Partida Chavez, Female

Biomarkers: HER2-positive

Irasema reported no evidence of breast cancer for 3 years after surgery and HER2-targeted treatment.

AACR
OutcomeCancer-Free / NED
Allison, who was diagnosed with Stage I Breast CancerBreast Cancer

Stage I HR-Positive Breast Cancer: Allison's Survivor Story

Patient Info: Allison Tierney, Female | Stage I

Biomarkers: ER-positive; PR-positive; HER2-positive

As of May 2024, Allison had recently completed her cancer treatment journey and reported successful hair preservation with cold capping during Taxol chemotherapy.

The Patient Story
OutcomeSurvivorship / Completed Treatment
A patient, who was diagnosed with Breast CancerBreast Cancer

HER2-positive apocrine breast cancer: chemotherapy and Herceptin

Patient Info: Anonymized, Female, 60s

Biomarkers: HER2-positive; AR-positive; ER-negative; PR-negative

Disease-free for 2 years after treatment for HER2-positive apocrine breast cancer, with no reported lymph-node recurrence or distant metastases during surveillance.

PubMed Central
OutcomeCancer-Free / NED
Allison, who was diagnosed with Stage II Invasive Ductal CarcinomaBreast Cancer

Stage II HR-Positive Invasive Ductal Carcinoma: Allison's Patient Story

Patient Info: Allison Tierney, Female | Stage II

Biomarkers: ER-positive; PR-positive; HER2-positive; CHEK2 mutation; BRCA1/2 negative

As of March 2024, Allison had completed Taxol and Herceptin treatment, was on tamoxifen planned for 10 years, and had moved to 6-month oncology follow-up. No metastatic disease or recurrence was reported.

YouTube — The Patient Story
OutcomeCare Ongoing
Dorian, who was diagnosed with Stage II Invasive Ductal CarcinomaBreast Cancer

Stage II HR-Positive Invasive Ductal Carcinoma: Dorian's Survivor Story

Patient Info: Dorian de Salvo, Female | Stage II

Biomarkers: ER-positive; PR-positive; HER2-positive

As of March 2024, Dorian had a complete response to TCHP chemotherapy, clear surgical margins, and no lymph-node involvement after surgery, with radiation completed and additional care still expected for several months.

The Patient Story
OutcomeCancer-Free / NED
A patient, who was diagnosed with Invasive Lobular CarcinomaBreast Cancer

Male Invasive Lobular Breast Cancer With a Pathogenic PALB2 Variant

Patient Info: Anonymized, male, 40s

Biomarkers: ER-positive; PR-positive; HER2 not amplified; pathogenic PALB2 variant

He was disease-free at 1-year follow-up after mastectomy, chemotherapy, and radiotherapy.

PubMed Central
OutcomeCancer-Free / NED
A patient, who was diagnosed with Stage IV Invasive Ductal CarcinomaBreast Cancer

Metastatic HER2-Positive Breast Cancer With Treatment-Related Telangiectasias

Patient Info: Anonymized, female, 60s | Stage IV

Biomarkers: HER2-positive; initially ER-negative and PR-negative; metastatic disease weakly ER-positive and PR-negative; germline testing negative

Metastatic Site: left supraclavicular, mediastinal, axillary and…

Living with HER2-positive breast cancer for 9+ years since her 2014 diagnosis, including metastatic disease since 2017. She remained on reduced-dose tucatinib in 2023 while treatment-related telangiectasias improved after dose reduction and electrocautery.

PubMed Central
OutcomeLiving With Cancer
A patient, who was diagnosed with Breast CancerBreast Cancer

HER2-Positive Mucoepidermoid Breast Cancer With 61 Months Without Recurrence

Patient Info: Anonymized, female, 50s

Biomarkers: HER2-positive; ER low expression; PR-negative

She was alive without signs of recurrence after 61 months of follow-up, providing just over 5 years of documented follow-up for this second primary breast cancer.

PubMed Central
OutcomeCancer-Free / NED
A patient, who was diagnosed with Stage I Breast CancerBreast Cancer

Five Years Without Breast Cancer Recurrence Despite a Markedly Elevated CA 15-3

Patient Info: Anonymized, female, 70+ | Stage I

Biomarkers: ER-positive, PR-positive, HER2-positive

Five years after her Stage I breast-cancer diagnosis, breast imaging and systemic evaluation showed no evidence of recurrence. The markedly elevated CA 15-3 was traced to a separate renal tumor and normalized after nephrectomy.

PubMed Central
OutcomeCancer-Free / NED
A patient, who was diagnosed with Stage IV Breast CancerBreast Cancer

Metastatic breast cancer: three years in remission with T-DM1 (Kadcyla) treatment

Patient Info: Anonymized, Female | Stage IV

Biomarkers: HER2-positive; hormone receptor-positive

Metastatic Site: liver; spine / bone

T-DM1 produced a complete clinical and radiological response after 7 cycles, sustained for 41 months and 60 cycles while treatment continued.

PubMed Central
OutcomeComplete Response
Olivia, who was diagnosed with Stage IV Inflammatory Breast CancerBreast Cancer

Stage IV HER2-Positive Inflammatory Breast Cancer: Olivia's Survivor Story

Patient Info: Olivia Franz, Female, Under 40 | Stage IV

Biomarkers: HER2-positive

Metastatic Site: Bones; distant lymph nodes

As of October 2023, Olivia continued to show no evidence of disease on scans while receiving maintenance trastuzumab and pertuzumab every 3 weeks and zoledronic acid every 3 months for bone health.

MD Anderson
OutcomeCancer-Free / NED
Nikki, who was diagnosed with Stage III Inflammatory Breast CancerBreast Cancer

Stage III HER2-Positive Inflammatory Breast Cancer: Nikki's Patient Story

Patient Info: Nikki, Female | Stage III

Biomarkers: HER2-positive; hormone receptor-positive

After 7 chemotherapy rounds, imaging showed no visible disease, but the team expected possible microscopic cancer. A single mastectomy, radiation and long-term hormone therapy were still planned, so she was not classified as cancer-free.

The Patient Story
OutcomeCare Ongoing / Surgery Planned
Abigail, who was diagnosed with Stage IV Breast CancerBreast Cancer

Stage IV HR-Positive Breast Cancer: Abigail's Patient Story

Patient Info: Abigail Myers, female, Under 40 | Stage IV

Biomarkers: ER-positive, PR-positive, HER2-positive

Metastatic Site: bones, brain

Abigail continued living with Stage IV metastatic breast cancer after about 8 years of multiple treatment lines, including therapy for bone and brain metastases.

Dana-Farber
OutcomeLiving With Cancer
A patient, who was diagnosed with Stage II Invasive Ductal CarcinomaBreast Cancer

HER2-positive breast cancer on hemodialysis: partial response to T-DM1 then no metabolically active disease

Patient Info: Anonymized, Female, 60s | Stage II

Biomarkers: Hormone receptor-positive; HER2/neu-positive; E-cadherin-positive; Ki-67 55-60%; luminal B type

As of March 2023, after 12 total cycles of T-DM1 and modified radical mastectomy, PET-CT showed no metabolically active disease, and she continued endocrine therapy and dialysis.

PubMed Central
OutcomeCancer-Free / NED
Lanie, who was diagnosed with Stage II Invasive Ductal CarcinomaBreast Cancer

Stage II HER2-Positive Invasive Ductal Carcinoma: Lanie's Patient Story

Patient Info: Lanie Jones, Female, Under 40 | Stage II

Biomarkers: HER2-positive; Li-Fraumeni syndrome / TP53 mutation; BRCA-negative

As of January 2023, Lanie was living with Li-Fraumeni syndrome after 5 cancer diagnoses and was on lifelong maintenance chemotherapy while advocating for genetic testing and specialized surveillance.

The Patient Story
OutcomeCare Ongoing