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A 63-year-old woman was referred for treatment of a newly identified gastric tumor. Endoscopy showed a small reddish polyp in the upper stomach next to an isochromatic polyp thought to be a fundic gland polyp. Several other fundic gland polyps were also present. She had no history of proton-pump inhibitor use, and testing for Helicobacter pylori was negative.
Although the biopsy of the reddish lesion was initially suspicious for an adenoma, its endoscopic appearance raised concern for malignancy. The two adjacent polyps were removed by endoscopic submucosal dissection.
Pathology confirmed a very well-differentiated gastric adenocarcinoma measuring 3 by 3 mm arising in a fundic gland polyp and confined to the mucosa. The neighboring polyp was a fundic gland polyp without dysplasia.
This is a lay summary of an account first published by PMC / PubMed Central. Read the original in full
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