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A 68-year-old man undergoing a medical checkup was found to have a small reddish polyp in the upper stomach next to another polyp that looked like a typical fundic gland polyp. He did not have a history of proton-pump inhibitor use or familial adenomatous polyposis, and testing for Helicobacter pylori was negative.
The reddish lesion was about 5 mm on endoscopy and had irregular surface and vascular patterns that raised concern for cancer. Biopsy was suspicious for differentiated gastric adenocarcinoma. Both the reddish lesion and the neighboring polyp were removed together by endoscopic submucosal dissection.
Pathology showed a very well-differentiated adenocarcinoma measuring 4 by 4 mm arising in a fundic gland polyp and confined to the mucosa. The adjacent polyp was a fundic gland polyp without dysplasia.
This is a lay summary of an account first published by PMC / PubMed Central. Read the original in full
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