AFP-producing gastric adenocarcinoma causes biliary obstruction without liver metastasis

This gastric cancer diagnosis at a glance

Subtype
Adenocarcinoma
Biomarkers
markedly elevated serum AFP
Sex
Female
Treatment
chemotherapy and palliative care
Outcome
Living With Cancer

Treatment course, step by step

  1. Received one reduced-dose treatment with gemcitabine because biliary obstruction limited chemotherapy options.
  2. Further chemotherapy was stopped after clinical deterioration.
  3. Transitioned to comfort-focused care.

What happened, in summary

A 33-year-old woman presented after 6 months of upper-abdominal pain, a growing mass, weight loss and poor appetite. Imaging showed a very large upper-abdominal tumor arising from the stomach and compressing the liver hilum and bile ducts, but repeat imaging did not show liver metastasis. Her serum alpha-fetoprotein, or AFP, was markedly elevated, and repeated tissue sampling supported gastric adenocarcinoma.

As the tumor enlarged, she became increasingly cachectic and could not maintain adequate nutrition. A feeding tube and biliary drainage catheter were placed to support nutrition and relieve the obstruction. Because her bilirubin remained severely abnormal, standard gastric-cancer regimens were not feasible. She received one reduced-dose treatment with gemcitabine.

Her clinical condition initially improved but then deteriorated, preventing further chemotherapy. Care became comfort-focused, and she was discharged in stable condition to Saint Vincent Island with her family.

Where this story comes from

This is a lay summary of an account first published by PMC / PubMed Central. Read the original in full

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