Stage II HR-Positive Invasive Lobular Carcinoma: Eutha's Survivor Story

This breast cancer diagnosis at a glance

Stage at diagnosis
Stage II
Subtype
Invasive Lobular Carcinoma
Biomarkers
ER-positive; PR-positive; HER2-positive
Sex
Female
Treatment
immunotherapy, a clinical trial, surgery, chemotherapy, radiation and reconstruction
Outcome
Survivorship / Surveillance

Treatment course, step by step

  1. Ipilimumab immunotherapy injection as part of an MSK clinical trial before surgery
  2. right mastectomy with removal of several lymph nodes
  3. 3 months of chemotherapy
  4. 5 weeks of radiation
  5. TRAM flap breast reconstruction about 8 months after radiation, with reduction surgery on the other breast for symmetry.

What happened, in summary

Eutha Prince was diagnosed with Stage II invasive ductal and lobular breast carcinoma in 2012 after a suspicious finding on her yearly mammogram led to ultrasound and biopsy. Her tumor was estrogen receptor-positive, progesterone receptor-positive and HER2-positive, which helped her MSK team tailor treatment. Eutha needed surgery, but before the operation her doctors recommended an immunotherapy clinical trial for early-stage breast cancer. She received an injection of ipilimumab just days after diagnosis, before surgery, hoping the immune-based approach might improve outcomes for patients like her. She then had a right mastectomy and several lymph nodes removed. Because chemotherapy and radiation were still needed after mastectomy, her doctors advised waiting on breast reconstruction. Eutha completed 3 months of chemotherapy followed by 5 weeks of radiation, with strong family support at each treatment. About 8 months after radiation ended, she had TRAM flap reconstruction using her own skin and fat to create a new breast, along with reduction surgery on the other breast so the 2 sides would match more closely. No explicit NED or cancer-free status was provided. After treatment and reconstruction, Eutha returned to work as a community board district manager and embraced survivorship as a second chance to continue serving West Harlem.

Where this story comes from

This is a lay summary of an account first published by Memorial Sloan Kettering. Read the original in full

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