Stage I Colorectal Cancer: Jay's Survivor Story

Patient Info: Jay Trevino, Male, 40s | Stage I

As of December 2024, Jay had Stage I colon cancer removed completely by laparoscopic surgery, was home within 24 hours, had a very good prognosis, and was planned for periodic blood tests and CT scans.

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Stage I Breast Cancer and a Separate Mixed Primary Liver Cancer in a 62-Year-Old Woman

Patient Info: Anonymized, Female, 60s | Stage I

Biomarkers: HER2/CerbB-2 positive

Postoperative pathology showed Stage I breast cancer, and the breast tumor did not progress.

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Stage I lung adenocarcinoma treated with SBRT after pacemaker relocation

Patient Info: Anonymized, Female, 70+ | Stage I

As of December 2024, CT showed complete resolution of the lung ground-glass lesion and no recurrence 4 years and 10 months after SBRT for Stage I lung adenocarcinoma, with stable pacemaker function.

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Stage I lung adenocarcinoma: post-lobectomy hemothorax resolved with tPA/DNase

Patient Info: Anonymized, Female, 70+ | Stage I

Early-stage lung adenocarcinoma was surgically treated with left upper lobectomy; postoperative hemothorax resolved after chest-tube drainage, bronchoscopy, and intrapleural tPA/DNase, with no hemothorax recurrence at follow-up.

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Rare squamous cell breast cancer: tumorectomy and partial mastectomy

Patient Info: Anonymized, Female, 40s | Stage I

Biomarkers: ER-negative; PR-negative; HER2-negative; Ki-67 21%, triple negative

As of August 2024, she had no recurrence 4 years after surgery, adjuvant AC/docetaxel chemotherapy, and residual breast irradiation for Stage I squamous cell carcinoma of the breast arising in a benign phyllodes tumor.

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Stage IIIA HR-positive HER2-negative breast cancer with radiation-induced brachial plexopathy

Patient Info: Anonymized, Female, 50s | Stage I

Biomarkers: HR-positive/HER2-negative breast cancer with pathogenic ATM and PALB2 variants plus an ATM VUS.

Approximately 3.5 years after radiation therapy, there was no evidence of breast cancer recurrence, but severe radiation-induced brachial plexopathy, fibrosis, telangiectasias, and lymphedema-related symptoms required ongoing supportive care.

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Stage III MET Exon 14-Positive Lung Adenocarcinoma Treated With Targeted Therapy Before Surgery

Patient Info: Anonymized, male, 60s | Stage I

Biomarkers: MET exon 14 skipping mutation; TP53 mutation

Postoperative pathology showed no involved lymph nodes and a lower pathologic Stage I group after treatment. No relapse was seen at the 6-month postoperative follow-up.

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Stage 1 lung adenocarcinoma: no recurrence after 2 years

Patient Info: Anonymized, Female, 50s | Stage I

No recurrence or surgical complications 2 years after uniportal video-assisted thoracoscopic left middle lobectomy and left upper-lobe wedge resection for Stage IB lung adenocarcinoma in situs inversus totalis.

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Stage 1 invasive ductal breast cancer: nipple-preserving mastectomy with reconstruction

Patient Info: Anonymized, Female, 60s | Stage I

Biomarkers: ER-positive; PR-positive; HER2-negative; Ki-67 28%

No signs of recurrence 20 months after nipple-preserving mastectomy, sentinel node biopsy, immediate reconstruction, adjuvant chemotherapy, and endocrine therapy for ER-positive, PR-positive, HER2-negative invasive ductal breast cancer.

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Stage 1 lung adenocarcinoma: NED after surgery alone

Patient Info: Anonymized, Male, 70+ | Stage I

Biomarkers: MET exon 14 skipping; PIK3CA p.; KRAS exon 2 p./D

Both independent early-stage lung adenocarcinomas were resected without lymph-node metastasis; follow-up showed normalized oncologic markers, negative lung-cancer autoantibodies, improved HRCT findings, and no recurrence for 1 year.

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Stage 1 EGFR lung adenocarcinoma treated with radiotherapy

Patient Info: Anonymized, Male, 70+ | Stage I

Biomarkers: EGFR exon 19 deletion; other common drivers not detected.

Stage IB EGFR exon 19 deletion lung adenocarcinoma was treated with definitive radiotherapy because of fragile condition after spinal cord infarction; at 5 months, the lesion showed no significant change and there was no recurrence or radiation pneumonitis.

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Stage I Invasive Lobular Carcinoma: Jessica's Patient Story

Patient Info: Jessica, Female, 40s | Stage I

Biomarkers: Myriad genetic testing negative; Oncotype DX score 19; RSClin recurrence risk 19%; isolated tumor cells around 1 sentinel lymph node without invasion

As of July 2024, Jessica had completed bilateral mastectomy for Stage IB ILC and was moving forward with radiation and long-term hormone suppression after chemotherapy was not recommended.

Lobular Breast Cancer AllianceRead more →

HER2-positive breast cancer: surgery after neoadjuvant therapy

Patient Info: Anonymized, Female, 60s | Stage I

Biomarkers: ER 1% weakly positive; PR-negative; HER2-positive

No evidence of disease on follow-up while taking anastrozole after pathologic complete response to neoadjuvant T-DM1, lumpectomy/SLNB, radiotherapy, and adjuvant trastuzumab for Stage I HER2-positive breast cancer.

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HER2-positive Stage I breast cancer: residual microinvasion after neoadjuvant T-DM1

Patient Info: Anonymized, Female, 70+ | Stage I

Biomarkers: ER-negative; PR-negative; HER2-positive

No evidence of disease on follow-up after neoadjuvant T-DM1, lumpectomy/SLNB showing only residual microinvasion/DCIS, continued adjuvant T-DM1 to 17 total cycles, and 52.5 Gy radiotherapy.

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Two early-stage primary lung cancers and bronchopleural fistula closure with VV-ECMO support

Patient Info: Anonymized, Male, 50s | Stage I

As of May 2024, the postoperative bronchopleural fistula had been successfully closed, the residual cavity had closed, and no BPF was seen on 3-month CT; longer cancer recurrence surveillance was not reported.

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Stage I EGFR Lung Adenocarcinoma: Phuong's Survivor Story

Patient Info: Phuong Ho, Female | Stage I

Biomarkers: EGFR alteration

Phuong has been cancer-free for 3 years and continues working on her lung capacity and overall fitness.

Stage I HR-Positive Breast Cancer: Allison's Survivor Story

Patient Info: Allison Tierney, Female | Stage I

Biomarkers: ER-positive; PR-positive; HER2-positive

As of May 2024, Allison had recently completed her cancer treatment journey and reported successful hair preservation with cold capping during Taxol chemotherapy.

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Stage I Invasive Lobular Carcinoma: Judith's Survivor Story

Patient Info: Judith, Female | Stage I

Judith’s very early Stage I ILC was found by a supplemental sonogram in June 2021, and she later described herself as cancer-free after working with an ILC-experienced oncology team.

Lobular Breast Cancer AllianceRead more →

Fertility-Sparing Treatment for Ovarian Immature Teratoma in a Young Woman

Patient Info: Anonymized, Female | Stage I

After fertility-sparing surgery, she remained disease-free under surveillance and later conceived naturally, completing a healthy term pregnancy.

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Stage I lung adenocarcinoma diagnosed alongside follicular lymphoma

Patient Info: Anonymized, male, 60s | Stage I

A 69-year-old man was found to have Stage I lung adenocarcinoma and a separate follicular lymphoma, allowing each cancer to be managed independently.

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Stage I papillary lung adenocarcinoma treated with robotic segmentectomy despite an abnormal pulmonary vein

Patient Info: Anonymized, male, 70+ | Stage I

One year after surgery, there was no lung-cancer recurrence and no respiratory or right-sided heart-failure symptoms.

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Stage I Breast Adenocarcinoma: Debbie's Survivor Story

Patient Info: Debbie Wade, Female | Stage I

As of February 2024, Debbie was cancer-free after double mastectomy, 4 weeks of radiation therapy and DIEP flap reconstruction for Stage I mucinous adenocarcinoma of the left breast, with mild left-arm lymphedema as the only reported side effect.

MD AndersonRead more →

Stage I Lung Cancer: Lauren's Patient Story

Patient Info: Lauren Koy, Female, Under 40 | Stage I

Biomarkers: CD56-positive neuroendocrine tumor; no gene mutations reported

As of January 2024, Lauren’s diagnosis had been established and bronchoscopy had reopened the blocked right-lung airway; later definitive treatment or long-term status was not described in this record.

The Patient StoryRead more →

Stage I lung squamous cell carcinoma: surgery and IMRT for localized tracheal recurrence

Patient Info: Anonymized, Male, 60s | Stage I

Three months after IMRT, PET-CT and bronchoscopy showed no residual tracheal lesion, no mediastinal lymph-node involvement, and no metastasis; he remained alive in the third year of follow-up with 6-month monitoring.

PubMed CentralRead more →